The mitotic checkpoint gene,SILis regulated byE2F1
نویسندگان
چکیده
منابع مشابه
Regulated Inactivation of the Spindle Assembly Checkpoint without Mitotic Spindles
Thank you for submitting your manuscript for consideration by The EMBO Journal. It has now been evaluated by three referees, whose reports are copied below. Although these reviewers point to the somewhat descriptive nature of the study, they nevertheless consider the main novel observation of apparently autonomous spindle checkpoint inactivation during prolonged mitotic arrest in Aspergillus po...
متن کاملBUBR1 phosphorylation is regulated during mitotic checkpoint activation.
Eukaryotic cells have evolved a mechanism that delays the progression of mitosis until condensed chromosomes are properly positioned on the mitotic spindle. To understand the molecular basis of such monitoring mechanism in human cells, we have been studying genes that regulate the mitotic checkpoint. Our early studies have led to the cloning of a full-length cDNA encoding MAD3-like protein (als...
متن کاملThe mitotic spindle checkpoint
One of the most awe-inspiring demonstrations in biology is a timelapse video of mitosis viewed with high magnification phase contrast or Nomarski DIC microscopy. From initial chaotic movement comes the orderly alignment of chromosomes at the metaphase plate followed by a flawlessly synchronous splitting of the chromosomes and their gliding separation to the two mitotic poles. Enforcing the timi...
متن کاملRegulated inactivation of the spindle assembly checkpoint without functional mitotic spindles.
The spindle assembly checkpoint (SAC) arrests mitosis until bipolar attachment of spindle microtubules to all chromosomes is accomplished. However, when spindle formation is prevented and the SAC cannot be satisfied, mammalian cells can eventually overcome the mitotic arrest while the checkpoint is still activated. We find that Aspergillus nidulans cells, which are unable to satisfy the SAC, in...
متن کاملReplication checkpoint: Preventing mitotic catastrophe
A conserved network of signal transduction pathways prevents mitosis if DNA is damaged or its synthesis incomplete. Loss of this checkpoint control is detrimental to the developing embryo. Recent studies have shed new light on how the essential ATR and Chk1 protein kinases cooperate to prevent such a crisis.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2008
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.23665